Amelioration of l-Dopa-Associated Dyskinesias with Triterpenoic Acid in a Parkinsonian Rat Model
| Autor: | Musa V. Mabandla, Babongile C. Ndlovu, Willie M. U. Daniels |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Dyskinesia Drug-Induced Levodopa Parkinson's disease Movement Substantia nigra Striatum Pharmacology Toxicology Neuroprotection Statistics Nonparametric Antiparkinson Agents Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Adrenergic Agents 0302 clinical medicine Parkinsonian Disorders Pregnancy Animals Medicine Oleanolic Acid Oxidopamine biology business.industry General Neuroscience Age Factors Extremities Catalase medicine.disease Glutathione Abnormal involuntary movement Rats nervous system diseases Disease Models Animal 030104 developmental biology Animals Newborn nervous system chemistry biology.protein Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurotoxicity Research. 29:126-134 |
| ISSN: | 1476-3524 1029-8428 |
| DOI: | 10.1007/s12640-015-9567-3 |
| Popis: | Levo-Dopa (L-Dopa) is widely used for the oral treatment of Parkinson's disease. However, chronic treatment with L-Dopa produces abnormal involuntary movements (AIMs) known as dyskinesias. In this study, commercially available oleanolic acid (OA) that has been previously shown to ameliorate the toxic effects of 6-hydroxydopamine (6-OHDA) in preconditioning studies was used to treat AIMs in a rat model for Parkinson's disease. The forelimb-use asymmetry test was used to measure Parkinson's disease-associated motor impairment. AIMs were measured after 21 days of L-Dopa administration. Glutathione levels were measured in blood, and catalase levels were measured in the substantia nigra and striatum of both the left and right hemispheres. We found that L-Dopa alone as well as L-Dopa and OA combination treatment attenuated the limb-use asymmetry caused by the unilateral injection of 6-OHDA. Chronic L-Dopa administration produced AIMs which were attenuated by treatment with OA. Catalase concentration decreased significantly in the striatum but not in the substantia nigra of the lesioned hemisphere. L-Dopa alone as well as the combined L-Dopa and OA treatment ameliorated the effects of 6-OHDA on catalase concentration. However, intervention with L-Dopa alone as well as with L-Dopa and OA did not affect plasma glutathione concentration. These results suggest that OA administration enhances the effect of catalase on reactive oxygen species following 6-OHDA injection. OA may provide possibilities as an adjunct treatment to prevent or attenuate the development of AIMs following chronic L-Dopa treatment in Parkinson's disease. |
| Databáze: | OpenAIRE |
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