Oxidative stress and neopterin abnormalities in schizophrenia: A longitudinal study
| Autor: | Naveen A. Reddy, Bangalore N. Gangadhar, Narendran Neelakantachar, K. Taranath Shetty, S. V. Suresh Babu, Ganesan Venkatasubramanian, Seetharamaiah Chittiprol |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Longitudinal study Antipsychotic treatment medicine.disease_cause Neopterin behavioral disciplines and activities Gastroenterology Pathogenesis chemistry.chemical_compound immune system diseases Internal medicine mental disorders medicine Humans Longitudinal Studies Psychiatry Biological Psychiatry medicine.disease Oxidative Stress Psychiatry and Mental health chemistry Schizophrenia Female Psychology After treatment Oxidative stress Antipsychotic Agents |
| Zdroj: | Journal of Psychiatric Research. 44:310-313 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2009.09.002 |
| Popis: | Oxidative stress abnormalities have been proposed to explain the pathogenesis of schizophrenia. The present study examined neopterin and oxidative stress abnormalities in schizophrenia patients before and after treatment. Serum neopterin, total anti-oxidants, nitrites and thiols in antipsychotic-naive schizophrenia patients ( n = 45) were assessed at baseline before treatment in comparison with healthy controls ( n = 43). The schizophrenia patients on treatment were followed up for 3 months and these parameters were reassessed ( n = 32). In comparison to healthy controls, schizophrenia patients had significantly higher levels of neopterin and nitrites and significantly lower levels of anti-oxidants before treatment. During follow-up assessments in schizophrenia patients after treatment with antipsychotics, there was a significant decrease in the neopterin levels and significant increase in anti-oxidant levels. Our study observations support increased oxidative stress in schizophrenia that improves with antipsychotic treatment. |
| Databáze: | OpenAIRE |
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