Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk
| Autor: | Michael D. Evans, Howard H.F. Tang, James E. Gern, Anna Lang, Louise M. Judd, Patrick G. Holt, Robert F. Lemanske, Kathryn E. Holt, Shu Mei Teo, Daniel J. Jackson, Kristine E. Lee, Rose F. Vrtis, Michael Inouye, Ronald E. Gangnon |
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| Přispěvatelé: | Tang, Howard [0000-0001-6422-0270], Inouye, Michael [0000-0001-9413-6520], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Allergy Adolescent Immunology medicine.disease_cause Article Gee 03 medical and health sciences 0302 clinical medicine children Risk Factors Nasopharynx RNA Ribosomal 16S COAST Childhood Origins of Asthma birth cohort study Immunology and Allergy Medicine Humans Microbiome Respiratory sounds MPG microbiome predominance group Respiratory system Child development Asthma Respiratory Sounds Childhood asthma medicine.diagnostic_test Bacteria business.industry Microbiota Infant birth cohort asthma medicine.disease RV rhinovirus 030104 developmental biology 030228 respiratory system Child Preschool Viruses Female RSV respiratory syncytial virus Rhinovirus business ASV amplicon sequence variant |
| Zdroj: | The Journal of Allergy and Clinical Immunology |
| DOI: | 10.17863/cam.60535 |
| Popis: | Background Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma. Objectives In this study, we tested whether developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses were related to risk of childhood asthma. Methods Children participating in the Childhood Origins of Asthma study (n=285) provided nasopharyngeal mucus samples in the first two years of life, during routine healthy study visits (2, 4, 6, 9, 12, 18 and 24 months of age) and episodes of respiratory illnesses, which were analyzed for respiratory viruses and bacteria. We identified developmental trajectories of early-life microbiome composition, as well as predominant bacteria during respiratory illnesses, and correlated these with presence of asthma at 6, 8, 11, 13 and 18 years of age. Results Of the four microbiome trajectories identified, a Staphylococcus-dominant microbiome in the first 6 months of life was associated with increased risk of recurrent wheezing by age 3 years and asthma that persisted throughout childhood. In addition, this trajectory was associated with the early onset of allergic sensitization. During wheezing illnesses, detection of rhinoviruses and predominance of Moraxella were associated with asthma that persisted throughout later childhood. Conclusion In infancy, the developmental composition of the microbiome during healthy periods and the predominant microbes during acute wheezing illnesses are both associated with the subsequent risk of developing persistent childhood asthma. Clinical Implication Identifying factors that promote early colonization with S. aureus may lead to future interventional studies to prevent childhood asthma. Capsule summary: In a birth cohort study, early colonization of the upper airway with Staphylococcus aureus and detection of rhinoviruses and Moraxella catarrhalis during illnesses were associated with subsequent childhood asthma. |
| Databáze: | OpenAIRE |
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