8OHdG as a marker for Huntington disease progression
| Autor: | Eric Epping, Anne Rosser, Nellie Georgiou-Karistianis, Roger Alistair Barker, Stacie Vik, Mirza Faisal Beg, Blair Leavitt, Katherine Koenig, Julie Stout, David Moser, Lynn Raymond, Anita Goh, Phyllis Chua, Hans Johnson, Thomas Wassink, Nicole Mans, WR Wayne Martin, Carissa Gehl, Michael Hayden, Georg Bernhard Landwehrmeyer, Jane Paulsen, Jeffrey Long, Vincent Magnotta, Jess Fiedorowicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cross-sectional study PREDICT-HD Posterior parietal cortex Physiology Disease medicine.disease_cause Mass Spectrometry Article lcsh:RC321-571 Pathogenesis Text mining Predictive Value of Tests Electrochemistry Leukocytes Humans Medicine Longitudinal Studies lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Chromatography High Pressure Liquid Aged Blood Specimen Collection 8OHdG business.industry Deoxyguanosine Biomarker Middle Aged Huntington disease Cross-Sectional Studies Neurology 8-Hydroxy-2'-Deoxyguanosine Oxidative stress Predictive value of tests Immunology Disease Progression Biomarker (medicine) Female business Mitochondrial dysfunction Biomarkers |
| Zdroj: | Neurobiology of Disease, Vol 46, Iss 3, Pp 625-634 (2012) |
| Popis: | Leukocyte 8-hydroxydeoxyguanosine (8OHdG) is an indicator of oxidative stress, impaired metabolism, and mitochondrial dysfunction, features that have been implicated in Huntington disease (HD). Increased levels of 8OHdG have been reported in the caudate, parietal cortex, and peripherally in the serum and leukocytes, in patients diagnosed with HD. However, little is known about levels in prodromal patients and changes that might occur as the disease progresses. To address these issues, 8OHdG was tracked over time for a subset of participants enrolled in the PREDICT-HD study. Participants were stratified into four groups based on proximity to HD diagnosis at study entry: Controls (gene-negative individuals), Low (low probability of near future diagnosis), Medium, and High. Blood samples were analyzed using Liquid Chromatography Electrochemical Array, and for comparison purposes, a separate cross-sectional sample was analyzed using liquid chromatography coupled with multiple-reaction-monitoring mass spectrometry. Longitudinal data analysis showed that initial status (at study entry) and annual rate of change varied as a function of proximity group, adjusting for sex, education, age at study entry, and site effects. Overall levels were lowest for the Control group and highest for the High group, and the rate of increase varied in a similar manner. The finding that 8OHdG concentrations increased as a function of proximity to projected disease diagnosis and duration indicates support for the continued assessment of 8OHdG as a robust clinical HD biomarker. |
| Databáze: | OpenAIRE |
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