The influence of bisoprolol dose on ADP-induced platelet aggregability in patients on dual antiplatelet therapy
| Autor: | Vladimir Ignjatovic, Ivica Petrovic, Dusan Paramentic, Sara Nikolic, Njegos Petrovic, Vladimir Miloradovic, Aleksandra Grdinić, Snezana Ignjatovic, Aleksandar Andjelkovic, Vesna Cokanovic, Slavisa Ignjatovic, Ivan Simic |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Platelet Aggregation Platelet Function Tests medicine.medical_treatment Risk Assessment Pharmacotherapy Predictive Value of Tests Risk Factors Internal medicine Angioplasty Coronary stent medicine Bisoprolol Humans Prospective Studies Angioplasty Balloon Coronary Aged Dose-Response Relationship Drug business.industry Percutaneous coronary intervention General Medicine Middle Aged medicine.disease Adrenergic beta-1 Receptor Antagonists Confidence interval Adenosine Diphosphate Concomitant Multivariate Analysis Cardiology Regression Analysis Drug Therapy Combination Female Stents Cardiology and Cardiovascular Medicine business Serbia Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Coronary Artery Disease. 21:472-476 |
| ISSN: | 0954-6928 |
| DOI: | 10.1097/mca.0b013e32833fd25b |
| Popis: | Purpose Dual antiplatelet therapy is recommended after acute coronary syndrome or after percutaneous coronary intervention with coronary stent implantation. Many of the patients on dual antiplatelet therapy receive β-blockers; some of them could have antiaggregatory effect. Bisoprolol is a highly selective adrenoceptor-blocker, which is often used in the settings of percutaneous coronary intervention or acute coronary syndrome in patients on dual antiplatelet therapy. Its antiaggregative effect has not been extensively studied. Therefore, the aim of this study is to investigate the effect of bisoprolol on ADP-induced platelet aggregation in patients on dual antiplatelet therapy. Methods Platelet aggregability has been measured in 100 patients on dual antiplatelet therapy with multiplate analyzer using ADP test in blood samples anticoagulated with heparin. ADP test values have been expressed by arbitrary units/minute. In univariate and multivariate regression analyses, we have investigated the influence of bisoprolol and its dose and also different factors, such as risk factors, concomitant drugs and their dosage, laboratory findings, on ADP test values. Results Univariate regression analysis showed significant correlation between the bisoprolol dose and the ADP test value (P=0.046, B=52.55, 95% confidence interval 0.87-104.23), which was also shown in the multivariate regression analysis (P=0.018; B=57.011; 95% confidence interval 10.455-103.567). Conclusion We have identified a positive correlation between bisoprolol dose and ADP-induced platelet aggregability in patients on dual antiplatelet therapy. |
| Databáze: | OpenAIRE |
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