The Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response
| Autor: | Duygu Yalinbas Yeter, Ayşe Vural Özeç, Erman Bozali, Serap Eroglu, Baris Sariakcali, Haydar Erdoğan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Neutrophils Visual Acuity Angiogenesis Inhibitors Gastroenterology Macular Edema Monocytes chemistry.chemical_compound High-density lipoprotein Internal medicine Diabetes mellitus medicine Diabetes Mellitus Immunology and Allergy Humans Lymphocytes Neutrophil to lymphocyte ratio Macular edema Retrospective Studies Diabetic Retinopathy business.industry fungi Retinal Diabetic retinopathy medicine.disease eye diseases Ophthalmology Cross-Sectional Studies chemistry Intravitreal Injections business Lipoproteins HDL Tomography Optical Coherence Retinopathy Lipoprotein |
| Zdroj: | Ocular immunology and inflammation. 30(4) |
| ISSN: | 1744-5078 |
| Popis: | Purpose: To determine the association of monocyte-to-high-density lipoprotein ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) with diabetic macular edema (DME) and early anti-VEGF treatment response.Material methods: This was a retrospective and cross-sectional study conducted with 143 patients with diabetes mellitus (53 diabetic retinopathy with DME, 38 diabetic retinopathy without DME, and 52 without diabetic retinopathy).Results: 13.9 was the best cutoff value to predict DME for MHR, and 2 was for NLR (59% and 75% sensitivity and 81% and 59% specificity, respectively). Logistic regression analysis showed that NLR≥2 and MHR≥13.9 were significantly associated with DME prediction. However, neither NLR≥2 nor MHR≥13.9 was associated with central retinal thickness(CRT) or best corrected visual acuity(BCVA) outcomes after anti-VEGF treatment. On the other hand, increased NLR was associated with inferior CRT outcomes.Conclusion: MHR and NLR were simple and cost-effective biomarkers to predict DME. Moreover, higher NLR may contribute to poor CRT outcomes. |
| Databáze: | OpenAIRE |
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