Dendro-somatic synaptic inputs to ganglion cells contradict receptive field and connectivity conventions in the mammalian retina
| Autor: | Morgan Musgrove, Joshua H. Singer, Miloslav Sedlacek, Hua Tian, Mrinalini Hoon, Fred Rieke, William N. Grimes, Amurta Nath, Jeffrey S. Diamond |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Population
Channelrhodopsin Biology Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology Article Retina Mice Postsynaptic potential Interneurons medicine Animals education Mammals education.field_of_study Dendrites Inner plexiform layer medicine.anatomical_structure Amacrine Cells nervous system Receptive field Synapses Excitatory postsynaptic potential sense organs General Agricultural and Biological Sciences Neuroscience |
| Zdroj: | Curr Biol |
| Popis: | The morphology of retinal neurons strongly influences their physiological function. Ganglion cell (GC) dendrites ramify in distinct strata of the inner plexiform layer (IPL) so that GCs responding to light increments (ON) or decrements (OFF) receive appropriate excitatory inputs. This vertical stratification prescribes response polarity and ensures consistent connectivity between cell types, whereas the lateral extent of GC dendritic arbors typically dictates receptive field (RF) size. Here, we identify circuitry in mouse retina that contradicts these conventions. AII amacrine cells are interneurons understood to mediate “cross-over” inhibition by relaying excitatory input from the ON layer to inhibitory outputs in the OFF layer. Ultrastructural and physiological analyses show, however, that some AIIs deliver powerful inhibition to OFF GC somas and proximal dendrites in the ON layer, rendering the inhibitory RFs of these GCs smaller than their dendritic arbors. This OFF pathway, avoiding entirely the OFF region of the IPL, challenges several tenets of retinal circuitry. These results also indicate that subcellular synaptic organization can vary within a single population of neurons according to their proximity to potential postsynaptic targets. |
| Databáze: | OpenAIRE |
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