Chlorhexidine sustained-release varnishes for catheter coating - Dissolution kinetics and antibiofilm properties
| Autor: | David Kirmayer, Batya Zaks, Eran Lavy, Michael Friedman, Doron Steinberg, Julia Gefter |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Catheters medicine.drug_class 030106 microbiology Varnish Pharmaceutical Science engineering.material Microbiology 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Coating Antiseptic medicine Dissolution testing Dissolution Chemistry Chlorhexidine Biofilm 030206 dentistry Catheter Drug Liberation Kinetics visual_art Biofilms Delayed-Action Preparations Pseudomonas aeruginosa visual_art.visual_art_medium engineering Anti-Infective Agents Local Nuclear chemistry medicine.drug |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 112 |
| ISSN: | 1879-0720 |
| Popis: | Catheter-associated urinary tract infections are difficult to eradicate or prevent, due to their biofilm-related nature. Chlorhexidine, a widely used antiseptic, was previously found to be effective against catheter-related biofilms. For the present study, we developed sustained-release chlorhexidine varnishes for catheter coating and evaluated their antibiofilm properties and chlorhexidine-dissolution kinetics under various conditions. The varnishes were based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit® RL). Chlorhexidine was released by diffusion from a heterogeneous matrix in the case of the ethylcellulose-based formulation, and from a homogeneous matrix in the case of Eudragit® RL. This dictated the release pattern of chlorhexidine under testing conditions: from film specimens, and from coated catheters in a static or flow-through system. Momentary saturation was observed with the flow-through system in Eudragit® RL-based coatings, an effect that might be present in vivo with other formulations as well. The coatings were retained on the catheters for at least 2weeks, and showed prolonged activity in a biological medium, including an antibiofilm effect against Pseudomonas aeruginosa. The current study demonstrates the potential of catheter coatings with sustained release of chlorhexidine in the prevention of catheter-associated urinary tract infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect