A new bioinspired peptide on defensin from C. annuum fruits: Antimicrobial activity, mechanisms of action and therapeutical potential

Autor: Gabriel Bonan, Taveira, Érica, de Oliveira Mello, Thatiana Lopes Biá Ventura, Simão, Milena Bellei, Cherene, André, de Oliveira Carvalho, Michelle Frazão, Muzitano, Elena, Lassounskaia, Saulo, Pireda, Emílio, de Castro Miguel, Luis Guilherme Mansor, Basso, Maura, Da Cunha, Olney Vieira, da Motta, Valdirene Moreira, Gomes
Rok vydání: 2022
Předmět:
Zdroj: Biochimica et Biophysica Acta (BBA) - General Subjects. 1866:130218
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2022.130218
Popis: Antimicrobial peptides, natural or synthetic, appear as promising molecules for antimicrobial therapy because of their both broad antimicrobial activity and mechanism of action. Herein, we determine the anti-Candida and antimycobacterial activities, mechanism of action on yeasts, and cytotoxicity on mammalian cells in the presence of the bioinspired peptide CaDef2.1CaDef2.1CaDef2.1The results obtained showed that CaDef2.1We show a new AMP bioinspired with physicochemical characteristics important for selectivity and antimicrobial activity, which is a promising candidate for drug development, mainly to control Candida infections.
Databáze: OpenAIRE
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