TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles

Autor:	Metin Kayalar, Asuman Aybey, Ayhan S. Demir
Rok vydání:	2005
Předmět:	lcsh:QD241-441 Annulation chemistry.chemical_compound lcsh:Organic chemistry Chemistry Propynyl Organic Chemistry Aromatization Regioselectivity Organic chemistry Amination Catalysis
Zdroj:	ARKIVOC, Vol 2005, Iss 15, Pp 105-116 (2005)
ISSN:	1551-7012
DOI:	10.3998/ark.5550190.0006.f15
Popis:	Highly flexible and efficient syntheses of 1,2,3,5-substituted pyrroles starting from 2-propynyl- 1,3-dicarbonyl compounds and amines are presented. TFA catalyzed formation of the pyrroles is suggested to proceed through sequential amination of the carbonyl compounds followed by regioselective 5-exo-dig cyclization of the enaminone intermediate and aromatization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b943334aafd95e8a28fd1d44317255d https://doi.org/10.3998/ark.5550190.0006.f15 Zobrazit plný text záznamu