IMPACT OF PROGESTERONE AND ESTRADIOL CONCENTRATION RATIO ON THE DAY OF FINAL OOCYTE MATURATION TRIGGER INJECTION ON PREGNANCY RATE AND OVARIAN HYPERSTIMULATION SYNDROME RISK IN WOMEN UNDERGOING VITRO FERTILIZATION

Autor:	С. В. Жуковская (S. V. Zhukovskaya)
Rok vydání:	2019
Předmět:	In vitro fertilisation business.industry medicine.medical_treatment lcsh:R lcsh:Medicine Ovarian hyperstimulation syndrome medicine.disease Andrology Pregnancy rate ivf ovarian hyperstimulation syndrome medicine infertility business hormones hormone substitutes and hormone antagonists
Zdroj:	Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, Vol 17, Iss 5, Pp 592-596 (2019)
ISSN:	2413-0109 2221-8785
DOI:	10.25298/2221-8785-2019-17-5-592-596
Popis:	Background. Progesterone and estradiol concentrations play a crucial role in implantation. Aim.To assess progesterone and estradiol concentration ratio impact on pregnancy rate and ovarian hyperstimulation syndrome risk (OHSS). Material and methods.We studied 718 patients in vitro fertilization programs (IVF) in “Center of Reproductive Medicine” (Minsk, Belarus). We measured serum levels of progesterone and estradiol on the day of final oocyte maturation trigger injection and assessed P4/E2 ratio. Results. P4/E2 ratio > 0,79 was associated with IVF failure with high sensitivity and specificity (Se 88,9%; Sp 89,1%). No correlation was established between P4/E2 and OHSS. Conclusions. P4/E2 ratio is a valuable prognostic marker of IVF efficacy, but it has no prognostic value in predicting OHSS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9343182a7ae015e8c8123fdb87f219 https://doi.org/10.25298/2221-8785-2019-17-5-592-596 Zobrazit plný text záznamu