The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women

Autor:	Eliza Kubicka, Felicja Lwow, Diana Jedzrzejuk, Andrzej Milewicz, Łukasz Łaczmański, Katarzyna Dunajska, U. Tworowska-Bardziñska
Rok vydání:	2008
Předmět:	medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Calcitriol receptor Body Mass Index Endocrinology Insulin resistance Gene Frequency Internal medicine medicine Vitamin D and neurology Humans Body Weights and Measures Genetic Predisposition to Disease Obesity Deoxyribonucleases Type II Site-Specific Metabolic Syndrome business.industry Obstetrics and Gynecology Middle Aged medicine.disease Lipids Postmenopause Receptors Calcitriol Blood sugar regulation Female Metabolic syndrome Insulin Resistance business Body mass index Biomarkers Polymorphism Restriction Fragment Length
Zdroj:	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 24(9)
ISSN:	1473-0766
Popis:	Vitamin D could have a direct effect on adipocyte differentiation and metabolism and might be involved in glucose regulation of insulin secretion. In recent years several polymorphisms in the gene encoding the vitamin D receptor (VDR), which are potent to alter the activity of VDR protein, have been described. The present study aimed to investigate the prevalence of the VDR BsmI polymorphism and its association with anthropometric and biochemical features of metabolic syndrome in postmenopausal women.We studied 351 randomly selected healthy postmenopausal women, with mean age of 55.43 +/- 2.75 years and mean body mass index (BMI) of 27.5 +/- 4.78 kg/m2, to evaluate the frequency of BsmI polymorphism (by restriction fragment length polymorphism-polymerase chain reaction) in the VDR gene and to find out whether there is an association between this polymorphism and BMI, total fat volume and visceral fat (as determined by total body dual-energy X-ray absorptiometry), blood pressure, lipid profile (total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglycerides) glucose and fasting insulin in the whole group, as well as subgroups of obese and non-obese women.The prevalence of BsmI genotypes in the study group was 51.0% Bb, 37.3% bb and 11.7% BB. Genotype distribution did not differ from that expected under Hardy-Weinberg equilibrium conditions (chi2 = 2.95, p = 0.22). Apart from LDL-C levels (F = 3.46, p = 0.032), there were no significant differences in anthropometric or metabolic parameters between genotypes.The BsmI polymorphism in the VDR gene does not seem to predispose to obesity and insulin resistance, but the BB genotype is connected with an unfavorable lipid profile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b88568750d288c225d93fdf00889be4 https://pubmed.ncbi.nlm.nih.gov/18958772 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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