Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
| Autor: | Ya Zhang, Shujun Gu, Zhengyuan Zhou, Dong Liu, Man Yang, Qiuyi Zhang, Hui Zuo, Cuicui Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty China Population diabetes & endocrinology Brain Ischemia Cohort Studies Risk Factors Diabetes mellitus Internal medicine medicine Humans Prospective Studies Prospective cohort study education Stroke education.field_of_study business.industry Proportional hazards model General Medicine Fasting medicine.disease stroke Quartile Cohort Female epidemiology Public Health business Cohort study |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesDiabetes mellitus has been associated with stroke. However, the association between fasting blood glucose (FBG) and stroke risk in a general population remains not clear. The purpose of our study was to examine the FBG levels on subsequent stroke risk in a community-based cohort in China.DesignProspective cohort study, employing Cox proportional hazard model to analyse the association of FBG levels with stroke risk.SettingA community-based cohort study included adults participating in a baseline survey conducted in 2013 in Changshu, eastern China.Participants16 113 participants were recruited with a multistage sampling method, excluding participants with severe disability, severe cancer, severe psychiatric disturbance or previous stroke before enrolment.Primary outcome measuresStroke events.ResultsDuring a median follow-up of 5.5 years, 417 incident cases of stroke were identified. The adjusted HR for total and ischaemic stroke for participants in the fourth quartile of FBG compared with the first quartile was 1.44 (95% CI 1.07 to 1.94) and 1.57 (95% CI 1.11 to 2.21), respectively. FBG levels of ≥7.0 mmol/L were associated with an increased risk of stroke based on two clinical classifications (American Diabetes Association: 1.68 (1.24 to 2.27); WHO: 1.62 (1.21, 2.13)). In stratified analyses, risk associations existed in women (HR: 1.92, 95% CI 1.22 to 3.01) and postmenopausal women (HR: 1.68, 95% CI 1.06 to 2.68) for the fourth quartile versus the first. More importantly, the meta-analysis observed a positive association between FBG levels and stroke risk (pooled HR: 1.70, 95% CI 1.27 to 2.29; n=7)).ConclusionsHigher FBG level was independently associated with an increased risk of stroke in Chinese adults, especially significant in women. |
| Databáze: | OpenAIRE |
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