Imaging methods in mechanosensing: a historical perspective and visions for the future
| Autor: | Kris Noel Dahl, Kirill Lavrenyuk, Daniel E. Conway |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Vision Extramural Perspective (graphical) Optical Imaging Biophysics Cell Differentiation Cell Biology Articles Biology Mechanotransduction Cellular Biomechanical Phenomena Extracellular Matrix 03 medical and health sciences Mechanobiology 0302 clinical medicine Human–computer interaction Animals Humans Molecular Biology Cell mechanics 030217 neurology & neurosurgery 030304 developmental biology Signal Transduction |
| Zdroj: | Molecular Biology of the Cell |
| ISSN: | 1939-4586 |
| Popis: | Over the past three decades, as mechanobiology has become a distinct area of study, researchers have developed novel imaging tools to discover the pathways of biomechanical signaling. Early work with substrate engineering and particle tracking demonstrated the importance of cell-extracellular matrix interactions on the cell cycle as well as the mechanical flux of the intracellular environment. Most recently, tension sensor approaches allowed directly measuring tension in cell-cell and cell-substrate interactions. We retrospectively analyze how these various optical techniques progressed the field and suggest our vision forward for a unified theory of cell mechanics, mapping cellular mechanosensing, and novel biomedical applications for mechanobiology. |
| Databáze: | OpenAIRE |
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