The use of discharge haemoglobin and NT-proBNP to improve short and long-term outcome prediction in patients with acute heart failure
| Autor: | Stojcevski, (Stojcevski, B., 1 ), Biljana), Celic, (Celic, V., 2 ), Vera), Navarin, Silvia, (Navarin, S., 3 ), Silvia), Pencic, (Pencic, B., 2 ), Biljana), Majstorovic, Sasa, (Majstorovic, A., 1 ), Anka), Sljivic, (Sljivic, A., 1 ), Aleksandra), Magrini, (Magrini, L., Laura), Cristofano, (Cristofano, F., 3 ), Flavia), Cavalieri, (Cavalieri, L., 3 ), Lavinia), Somma, Di, (Di Somma, S., Salvatore) |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics acute heart failure nt-probnp anaemia haemoglobin prognosis 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Hemoglobins 0302 clinical medicine Cause of Death Natriuretic Peptide Brain Natriuretic peptide Medicine 030212 general & internal medicine Cause of death Incidence Incidence (epidemiology) Anemia General Medicine Patient Discharge Survival Rate Italy Acute Disease Disease Progression Female Cardiology and Cardiovascular Medicine Risk assessment Serbia medicine.medical_specialty medicine.drug_class Patient Readmission Risk Assessment 03 medical and health sciences Humans In patient Protein Precursors Survival rate Aged Heart Failure business.industry medicine.disease Peptide Fragments ROC Curve Heart failure business Biomarkers |
| Popis: | To examine the prognostic value of admission (A) and discharge (D) haemoglobin (Hb) and its relationship with N-terminal pro-hormone B-type natriuretic peptide (NT-proBNP) in patients hospitalised for acute heart failure (AHF). The outcomes of interests were rehospitalisation or death after one, six or twelve months after discharge.317 hospitalised AHF patients (74.7±9.4 years) were enrolled in two academic centres in Belgrade and Rome. Laboratory analyses, including NT-proBNP were assessed at admission, and Hb also at discharge. Patients were divided into two groups according to the presence of anaemia. Follow-up contact was made by telephone. Statistical analyses were performed using SPSS software version 21.0.According to A and DHb levels (120 g/l for women and130 g/l for men), anaemia was present in 55% and 62% of patients, respectively ( P=0.497). Lower DHb was associated with the rehospitalisation risk after one (OR=0.96, P=0.004), six (OR=0.97, P0.001) and 12 months (OR=0.97, P0.001). For every g/l decrease of DHb, the risk of rehospitalisation after one year was increased by 3.3%. In the first six months, DHb contributed to increased risk of death (OR=0.97, P=0.005), but NT-proBNP showed greater power (OR=2.1, P0.001).In AHF patients discharge anaemia is a strong predictor for short and long-term rehospitalisation, while NT-proBNP seems to be a better predictor for mortality. Discharge Hb and NT-proBNP should be assessed together in order to detect the patients with higher risk of future death and rehospitalisation. |
| Databáze: | OpenAIRE |
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