Human leucocyte antigen (HLA) class I and II typing in Belgian multiple sclerosis patients
| Autor: | Vanda Holovska, Andreas Lysandropoulos, Judith Racapé, Michel Toungouz |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Multiple Sclerosis Population Human leukocyte antigen Gastroenterology 03 medical and health sciences 0302 clinical medicine Belgium Gene Frequency Internal medicine medicine Humans Genetic Predisposition to Disease Allele education Allele frequency education.field_of_study business.industry Histocompatibility Antigens Class I Haplotype Histocompatibility Antigens Class II General Medicine Odds ratio Middle Aged Confidence interval 030104 developmental biology Haplotypes Cohort Immunology Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Acta Neurologica Belgica. 117:61-65 |
| ISSN: | 2240-2993 0300-9009 |
| DOI: | 10.1007/s13760-016-0716-0 |
| Popis: | This is one of the first studies to compare the frequencies of different human leucocyte antigen (HLA) class I and II alleles and haplotype HLA-DRB1*15-DQB1*06 in a cohort of 119 patients with multiple sclerosis (MS) and a cohort of 124 healthy controls in Belgium. An association with MS was found for the HLA-DRB1*15 (odds ratio [OR] 2.60 [95% confidence interval (CI) 1.51-4.50]) and HLA-DQB1*06 (OR 1.97 [95% CI 1.18-3.29]) alleles, and for haplotype DRB1*15-DQB1*06 (OR 2.63 [95% CI 1.52-4.56]). The HLA-B*07 allele also tended to be more frequent in MS patients (OR 1.46 [95% CI 0.80-2.65]) and more frequent among MS patients with than in those without the HLA-DRB1*15 allele (26/54 [48.1%] versus 6/65 [9.2%]; p value |
| Databáze: | OpenAIRE |
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