Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands

Autor:	Federico Corelli, Claudia Mugnaini, Teresa Semeraro
Rok vydání:	2008
Předmět:	Set (abstract data type) Stereochemistry Chemistry Organic Chemistry Drug Discovery Moiety Ring (chemistry) Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 49:5965-5967
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2008.07.158
Popis:	A synthetic route for the preparation of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones characterized by a decorated benzyl moiety at different positions of the five-membered ring has been developed, and some compounds have been tested as Hsp90 ligands. One of them displayed IC50 = 50 μM representing an interesting starting point for further investigations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3f9562c651e829e21760817fae3a3a https://doi.org/10.1016/j.tetlet.2008.07.158 Zobrazit plný text záznamu Full Text from ScienceDirect