High shear mixing of lactose and salmeterol xinafoate dry powder blends: Biopharmaceutic and aerodynamic performances
| Autor: | Hartwig Steckel, Eike Cordts, Francesca Buttini, Paolo Colombo, Francesco Guarneri, Fabio Sonvico, Ruggero Bettini, Anna Giulia Balducci, Gaia Colombo, Alessandra Rossi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
High-shear mixer
Chromatography Materials science Microparticle dissolution Biopharmaceutics technology industry and agriculture Pharmaceutical Science High shear mixer SALMETEROL XINAFOATE Dry-powder inhaler NO Salmeterol xinafoate Easyhaler chemistry.chemical_compound Dry powder inhaler chemistry Chemical engineering Salmeterol xinafoate High shear mixer Easyhaler RS01 Dry powder inhaler Microparticle dissolution RS01 Dry powder Particle-size distribution Pharmacology & Pharmacy Lactose Dissolution |
| Popis: | © 2015 Elsevier B.V.All rights reserved. This work aimed to investigate the effect of a high shear mixer on the biopharmaceutics and aerodynamic performances of salmeterol xinafoate/lactose blends for inhalation. The influence of mixing energy during blending on powder bulk properties, aerosolisation and in vitro dissolution rate of drug was studied. There was a clear dependence of the blends bulk characteristics on the mixing rate and time that affected the emitted dose. The fine particle dose or respirable fraction of salmeterol xinafoate was favored by the mixing intensity leading to the disaggregation of the drug particles. An important dependence of the extra-fine drug particles on the mixing conditions was determined. The effective dispersion on the carrier particles of the salmeterol xinafoate improved the dissolution rate of the drug from the blend. This was due to the drug particle size distribution in the blend. When the fine particle dose of different blends was dissolved, no differences among the dissolution rates were observed. |
| Databáze: | OpenAIRE |
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