Stromal versus tumoral inflammation differentially contribute to metastasis and poor survival in laryngeal squamous cell carcinoma
| Autor: | Petra Altenhoff, Robert Michael Petri, O Kanaan, Stephan Lang, Kruthika Thangavelu, Agnes Bankfalvi, Anke Schlüter, Sven Brandau, Benedikt Höing |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Stromal cell leukocytes CD3 Medizin Inflammation Metastasis 03 medical and health sciences 0302 clinical medicine Immune system Stroma medicine cancer-related inflammation Tumor microenvironment biology business.industry Head and neck cancer tumor stroma medicine.disease 030104 developmental biology nodal metastasis Oncology 030220 oncology & carcinogenesis Cancer research biology.protein head and neck cancer medicine.symptom business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.23865 |
| Popis: | // Benedikt Hoing 1 , Oliver Kanaan 1 , Petra Altenhoff 1 , Robert Petri 1 , Kruthika Thangavelu 1 , Anke Schluter 1 , Stephan Lang 1 , Agnes Bankfalvi 2 and Sven Brandau 1 1 Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, Germany 2 Institute of Pathology, University Hospital Essen, Essen, Germany Correspondence to: Sven Brandau, email: Sven.Brandau@uk-essen.de Keywords: cancer-related inflammation; leukocytes; tumor stroma; head and neck cancer; nodal metastasis Received: May 30, 2017 Accepted: November 16, 2017 Published: January 03, 2018 ABSTRACT In solid tumors the biology and clinical course are strongly influenced by the interaction of tumor cells and infiltrating stromal host cells. The aim of this study was to assess the relative importance of stromal vs. tumoral inflammation for metastasis and survival in patients with laryngeal squamous cell carcinoma (LSCC). In 110 patients with tissues from histologically proven LSCC the expression of CD45, CD11b, CD3, MMP-9 and COX-2 was semiquantitatively analyzed in stromal regions and tumor nests. CD45, CD11b, CD3 and MMP-9 positive cells were more abundant in stroma whereas COX-2 was predominantly expressed in epithelial tumor nests. High expression of stromal CD45 and CD11b on immune cells in tumor regions correlated with COX-2 expression on tumor cells. High levels of CD45 in stroma as well as CD11b and COX-2 in tumor nests were associated with increased metastasis. In contrast, high frequencies of CD3 cells in the tumor core area were associated with reduced metastasis. Overall survival was reduced in patients with high stromal CD45, high tumoral CD11b and high tumoral COX-2 expression. This is the first study which separately analyzes peritumoral stroma and tumor core area in laryngeal squamous cell carcinoma in terms of CD45, CD11b, CD3, MMP-9 and COX-2 expression. Our results indicate that stroma and tumor islands need to be considered as two separate compartments in the inflammatory tumor microenvironment. Inflammatory stromal leukocytes, abundant myeloid cells in tumor regions and high expression of COX-2 on tumor cells are linked to metastatic disease and poor overall survival. |
| Databáze: | OpenAIRE |
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