Changes in serum phosphate during beta-blockade in healthy men are not due to changes in the renal handling of phosphate
| Autor: | Niels Fogh-Andersen, B. Jorgensen, J. E. Mølholm Hansen, L. Kayser, Hans Perrild |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Parathyroid hormone chemistry.chemical_element Calcium Kidney Phosphates chemistry.chemical_compound Random Allocation Internal medicine Internal Medicine Medicine Humans Metoprolol Calcium metabolism Creatinine Clinical Trials as Topic business.industry Phosphate Atenolol Propranolol Endocrinology chemistry Parathyroid Hormone Alkaline phosphatase business medicine.drug |
| Zdroj: | Journal of internal medicine. 225(3) |
| ISSN: | 0954-6820 |
| Popis: | Serum parathyroid hormone (PTH), phosphate, ionized calcium, magnesium, alkaline phosphatase and creatinine and the urinary excretion of phosphate and creatinine were studied after 1 and 3 weeks β-blockade in 32 young healthy men given either atenolol at 50 mg. metoprolol at 100 mg, propranolol at 80 mg or placebo twice a day. After 1 week treatment serum phosphate (mean (range)) increased in the propranolol-treated subjects (1.17 (0.99–1.30) to 1.32 (1.08–1.71) mmol l−1 (P = 0.03), minor changes were found in the atenolol and the metoprolol-treated subjects but not in the placebo group. Serum phosphate was unchanged compared to pretreatment values after 3 weeks. Renal clearance and urinary excretion of phosphate and creatinine was unchanged after both 1 and 3-weeks treatment. Serum PTH, ionized calcium, magnesium and alkaline phosphatase were unchanged in all groups, whereas serum urate and creatinine increased in the metoprolol-treated subjects after both 1 and 3 weeks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text