Statins and hip fracture risk in men: a population-based case-control study
| Autor: | Annette L. Adams, Jiaxiao M. Shi, T. Craig Cheetham, Reina Haque, Aniket A. Kawatkar, Donald C. Fithian, Kristi Reynolds, Steven J. Jacobsen |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Risk medicine.medical_specialty Epidemiology Health Behavior Population Comorbidity California Medication Adherence Internal medicine Ethnicity Odds Ratio medicine Humans education Prospective cohort study Aged Aged 80 and over Hip fracture education.field_of_study Dose-Response Relationship Drug Hip Fractures business.industry Incidence Incidence (epidemiology) Case-control study Odds ratio Middle Aged medicine.disease Confidence interval Cardiovascular Diseases Case-Control Studies Population Surveillance Physical therapy Hydroxymethylglutaryl-CoA Reductase Inhibitors business |
| Zdroj: | Annals of Epidemiology. 25:844-848 |
| ISSN: | 1047-2797 |
| Popis: | Purpose To estimate the association between hydroxymethylglutaryl-CoA inhibitor (statin) use and hip fracture. Methods We conducted a population-based case-control study. Cases were 6774 male enrollees in a large managed care organization, aged 45 or more years, with an incident hip fracture from 1997 to 2006. Controls without fracture ( n = 6774) were matched to cases on age, race, and medical center. Electronic information on pharmaceutical use was used to identify the dispensing of statins from 1991 forward. Results Overall, 1884 (27.8%) cases and 2150 controls (31.7%) used a statin before index date (matched odds ratio [mOR] = 0.81, 95% confidence interval [CI] = 0.74–0.87). Adjustment for comorbidity burden strengthened the magnitude of the overall association (mOR = 0.68, CI = 0.62–0.74). The adjusted association was similar across age groups but was strongest among men aged 80 years or more (mOR = 0.62, CI = 0.54–0.71) and was most pronounced in African Americans (mOR = 0.43, CI = 0.28–0.64). Greater duration of statin use did not alter the odds ratios. Conclusions These data add to the growing evidence of a potential protective effect of statin use on bone health. However, these results need to be replicated in a prospective study that can account for confounding by indication which may explain these findings. |
| Databáze: | OpenAIRE |
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