A large single-center experience with treatment of patients with crotalid envenomations: outcomes with and evolution of antivenin therapy
| Autor: | Ronald M. Stewart, Daniel L. Dent, John G. Myers, Peter P. Lopez, Scott Larson, Stephen M. Cohn, Michael G. Corneille, Marilyn J. McFarland |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Antivenom Poison control Snake Bites Single Center Amputation Surgical Internal medicine medicine Coagulopathy Viperidae Crotalidae polyvalent immune fab Animals Humans Envenomation Child Aged Retrospective Studies Aged 80 and over biology business.industry Antivenins Pit viper General Medicine Middle Aged biology.organism_classification medicine.disease Surgery Fasciotomy Treatment Outcome Amputation Child Preschool Female business |
| Zdroj: | American journal of surgery. 192(6) |
| ISSN: | 1879-1883 |
| Popis: | Background: Antivenin (crotalid) polyvalent (ACP; Antivenin Crotalidae Polyvalent; Wyeth, Melville, NY) is associated with frequent allergic reactions. Allergic reactions are fewer with ovine Fab antivenin (FabAV). This study describes the management of crotalid envenomations in patients treated with FabAV or ACP, and without antivenin. Methods: We performed a retrospective chart review of crotalid envenomations over 10 years. Demographic data, hematologic profiles, details of antivenin administration, and in-hospital morbidity and mortality were collected. Results: There were no mortalities and a single amputation. Fewer fasciotomies were performed in the FabAV (9%) group versus the ACP group (24%). Mean hospital stay was 3.4 days. No allergic reactions were associated with FabAV. Fourteen of 211 reactions were associated with ACP (P |
| Databáze: | OpenAIRE |
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