The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus
| Autor: | Baris Afsar, Emine M Onal, Adrian Covic, Tuncay Dagel, Mehmet Kanbay, Nosratola D. Vaziri, Aslihan Yerlikaya |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nephrology Kidney Disease Gut flora Systemic inflammation urologic and male genital diseases Kidney Oral and gastrointestinal Pathogenesis Chronic kidney disease 2.1 Biological and endogenous factors Renal Insufficiency Chronic Aetiology Proteinuria biology Diabetes Urology & Nephrology female genital diseases and pregnancy complications Hypertension medicine.symptom medicine.medical_specialty Urology Clinical Sciences Renal and urogenital Inflammation Gut microbiota digestive system Autoimmune Disease 03 medical and health sciences Internal medicine Diabetes mellitus medicine Diabetes Mellitus Animals Humans Renal Insufficiency Chronic Nutrition business.industry Probiotics biology.organism_classification medicine.disease Gastrointestinal Microbiome 030104 developmental biology Good Health and Well Being Immunology Dysbiosis business Kidney disease |
| Zdroj: | International urology and nephrology, vol 50, iss 8 Kanbay, M; Onal, EM; Afsar, B; Dagel, T; Yerlikaya, A; Covic, A; et al.(2018). The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus. INTERNATIONAL UROLOGY AND NEPHROLOGY, 50(8), 1453-1466. doi: 10.1007/s11255-018-1873-2. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/75g2g7zk |
| DOI: | 10.1007/s11255-018-1873-2. |
| Popis: | Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD. The gut microbiota closely interacts with the inflammatory, renal, cardiovascular, and endocrine systems via metabolic, humoral, and neural signaling pathways, events which can lead to chronic systemic inflammation, proteinuria, hypertension, diabetes, and kidney disease. Given the established role of the gut microbiota in the development and progression of CKD and its complications, favorable modification of the composition and function of the gut microbiome represents an appealing therapeutic target for prevention and treatment of CKD. This review provides an overview of the role of the gut microbial dysbiosis in the pathogenesis of the common causes of CKD including hypertension, diabetes, and proteinuria as well as progression of CKD. |
| Databáze: | OpenAIRE |
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