Tumor heterogeneity in lung cancer based on light microscopic features
| Autor: | Gyda Ottesen, Jens E. Olsen, Fred R. Hirsch, Jan Pødenphant |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Pathology
medicine.medical_specialty Cell type Lung Neoplasms Histology Biopsy Adenocarcinoma Tumor heterogeneity Pathology and Forensic Medicine medicine Humans Carcinoma Small Cell Lung cancer Prospective cohort study Molecular Biology Retrospective Studies Lung business.industry Retrospective cohort study Cell Biology General Medicine medicine.disease Phenotype medicine.anatomical_structure Homogeneous Carcinoma Squamous Cell Anatomy business |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 402:147-153 |
| ISSN: | 1432-2307 0340-1227 |
| Popis: | In order to study the problem of morphological tumor heterogeneity in lung cancer, 200 consecutive patients who had undergone surgery for a malignant lung tumor, were evaluated retrospectively with regard to morphological type. The tumor was classified morphologically in 187 patients, and 163 (87%) had a morphologically homogeneous tumor, based on light microscopic features and using the criteria recommended by the World Health Organization. The remaining 24 patients (13%) had a tumor with morphologic features of more than one cell type. It is concluded that morphological heterogeneity is a considerable problem in the classification of malignant lung tumors. This heterogeneity had been regarded as evidence of an endodermal origin of all major types of lung cancer. Future prospective studies will have to determine whether it has any therapeutic significance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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