The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica)
| Autor: | Zuoqing Yuan, Wenpeng Xin, Changchao Tu, Jianyong Zhang, Zhijing Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Monoamine oxidase Health Toxicology and Mutagenesis Blueberry Plants 010501 environmental sciences Mitochondrion 01 natural sciences Antioxidants Anthocyanins 03 medical and health sciences chemistry.chemical_compound Animals Cytochrome c oxidase 0105 earth and related environmental sciences Fluorocarbons biology Plant Extracts Succinate dehydrogenase fungi Public Health Environmental and Occupational Health food and beverages Planarians General Medicine biology.organism_classification Pollution Mitochondria carbohydrates (lipids) 030104 developmental biology chemistry Mitochondrial permeability transition pore Biochemistry Anthocyanin biology.protein Perfluorooctanoic acid Dugesia japonica Caprylates |
| Zdroj: | Ecotoxicology and Environmental Safety. 127:170-174 |
| ISSN: | 0147-6513 |
| Popis: | The influence of blueberry anthocyanins on perfluorooctanoic acid (PFOA)-induced stress response in planarian mitochondria was investigated. PFOA at 15mg/L and anthocyanins at 10 or 20mg/L were individually and simultaneously administered to planarians for up to 10d. The results showed PFOA treatment induced an increase in mitochondrial permeability transition pore opening and a decrease antioxidant capacity and enzyme activities. In anthocyanin treated animals, the activity of succinate dehydrogenase, cytochrome oxidase and monoamine oxidase increased, but mitochondrial permeability transition pore opening decreased and total antioxidant capacity increased. An improvement in above-mentioned physiological and biochemical parameters was found in the combined PFOA and anthocyanin treated animals, in a dose-dependent manner. Anthocyanins attenuated the PFOA induced toxicity; antioxidant capacity and enzyme activities are involved in the protective mechanism of anthocyanins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect