Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Autor: Mei Wei Lim, Ken Seethram, Mira Aubuchon, Marcelo J. Barrionuevo, Carlos Mario Gómez Gómez, Georgina Meneghini, Felipe Vilella, Alejandro Chavez, Carlos Simón, Alexandra Izquierdo, Martina Perez-Olgiati, Marta Gonzalez-Monfort, Sagiri Taguchi, Elena Puente, Mark Leondires, Inmaculada Moreno, David Perez-Villaroya, Michael Dimattina, Davide Bau, Diana Valbuena, Iolanda Garcia-Grau, Mustafa Bahceci
Rok vydání: 2022
Předmět:
Zdroj: Microbiome
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Microbiome, Vol 10, Iss 1, Pp 1-17 (2022)
ISSN: 2049-2618
DOI: 10.1186/s40168-021-01184-w
Popis: Background Previous evidence indicates associations between the female reproductive tract microbiome composition and reproductive outcome in infertile patients undergoing assisted reproduction. We aimed to determine whether the endometrial microbiota composition is associated with reproductive outcomes of live birth, biochemical pregnancy, clinical miscarriage or no pregnancy. Methods Here, we present a multicentre prospective observational study using 16S rRNA gene sequencing to analyse endometrial fluid and biopsy samples before embryo transfer in a cohort of 342 infertile patients asymptomatic for infection undergoing assisted reproductive treatments. Results A dysbiotic endometrial microbiota profile composed of Atopobium, Bifidobacterium, Chryseobacterium, Gardnerella, Haemophilus, Klebsiella, Neisseria, Staphylococcus and Streptococcus was associated with unsuccessful outcomes. In contrast, Lactobacillus was consistently enriched in patients with live birth outcomes. Conclusions Our findings indicate that endometrial microbiota composition before embryo transfer is a useful biomarker to predict reproductive outcome, offering an opportunity to further improve diagnosis and treatment strategies.
Databáze: OpenAIRE
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