Vinblastine, Ifosfamide, Gallium Nitrate, and Filgrastim in Platinum- and Paclitaxel-Resistant Ovarian Cancer
| Autor: | Joel I. Sorosky, Robert Dreicer, Jacqueline K. Joyce, Barrie Anderson, Richard E. Buller, Thomas A. Lallas |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
medicine.medical_specialty Filgrastim Paclitaxel medicine.medical_treatment Population Gallium Vinblastine Gastroenterology chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Humans Ifosfamide education Aged Mesna Ovarian Neoplasms Gallium nitrate Chemotherapy education.field_of_study business.industry Middle Aged Recombinant Proteins Carboplatin Surgery Regimen Oncology chemistry Drug Resistance Neoplasm Female Cisplatin business medicine.drug |
| Zdroj: | American Journal of Clinical Oncology. 21:287-290 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/00000421-199806000-00017 |
| Popis: | The authors performed a phase II trial of the VIG regimen (vinblastine, ifosfamide, and gallium nitrate) in patients who had advanced ovarian cancer who were refractory to cisplatin and/or carboplatin and whose disease had progressed after paclitaxel-based therapy. This was a heavily pretreated population, with five patients having received two to three prior chemotherapy regimens and six patients having received more than six prior chemotherapy regimens, with an average of 21 therapy cycles per patient. Fourteen patients were treated with vinblastine, 0.08 mg/kg intravenously on days 1 and 2; ifosfamide, 900 mg/m2 intravenously on days 1 through 5 with standard mesna uroprotection; and gallium nitrate administered as a continuous intravenous infusion at 225 mg/m2 per 24 hours x 120 hours. Granulocyte colony-stimulating factor (G-CSF) was administered subcutaneously at 5 microg/kg/day beginning on day 7 until day 13. Five of 14 patients achieved a partial response for an overall response rate of 36% (95% confidence interval, 14%-68%). The median response duration was 14 weeks. Toxicity was primarily hematologic, with anemia and leukopenia being most significant. There were no treatment-related deaths. Further evaluation of this regimen in a less heavily pretreated population is warranted. |
| Databáze: | OpenAIRE |
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