Impaired Behavioral Pattern Separation in Refractory Temporal Lobe Epilepsy and Mild Cognitive Impairment
| Autor: | Leena Kansal, Erik Kaestner, Brianna M. Paul, Carrie R. McDonald, Shauna M. Stark, Sanam J. Lalani, Craig E.L. Stark, Jerry J. Shih, Christine N. Smith, Anny Reyes, David Lee |
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| Rok vydání: | 2022 |
| Předmět: |
Aging
Hippocampus Audiology Neuropsychological Tests Neurodegenerative Medical and Health Sciences Epilepsy Cognition Medicine 2.1 Biological and endogenous factors Aetiology Episodic memory General Neuroscience Experimental Psychology Memory impairment Magnetic Resonance Imaging Temporal Lobe Psychiatry and Mental health Clinical Psychology Mental Health Neurological Seizure disorder Episodic medicine.medical_specialty Memory Episodic Verbal learning behavioral disciplines and activities Basic Behavioral and Social Science Article Temporal lobe Memory Clinical Research Behavioral and Social Science Acquired Cognitive Impairment Humans Cognitive Dysfunction Hippocampal sclerosis Memory Disorders business.industry Psychology and Cognitive Sciences Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) medicine.disease Brain Disorders Epilepsy Temporal Lobe Neurology (clinical) business |
| Zdroj: | Journal of the International Neuropsychological Society : JINS, vol 28, iss 6 J Int Neuropsychol Soc |
| ISSN: | 1355-6177 |
| Popis: | Objective:Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In this study, we examined behavioral PS in patients with TLE and explored whether profiles of performance in TLE are similar to aMCI.Method:Patients with TLE, aMCI, and age-matched, healthy controls (HCs) completed a modified recognition task that relies on PS for the discrimination of highly similar lure items, the Mnemonic Similarity Task (MST). Group differences were evaluated and relationships between clinical characteristics, California Verbal Learning Test—Second Edition scores, and MST performance were tested in the TLE group.Results:Patients with TLE and aMCI demonstrated poorer PS performance relative to the HCs, but performance did not differ between the two patient groups. Neither the side of seizure focus nor having hippocampal sclerosis affected performance in TLE. However, TLE patients with clinically defined memory impairment showed the poorest performance.Conclusion:Memory performance on a task that relies on PS was disrupted to a similar extent in TLE and aMCI. The MST could provide a clinically useful tool for measuring hippocampus-dependent memory impairments in TLE and other neurological disorders associated with hippocampal damage. |
| Databáze: | OpenAIRE |
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