Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams
| Autor: | Paul W. Joyner, Cheryl H. Walker, Deborah A. Lubin, Josephine M. Johns, Vivian E. Hofler, Matthew S. McMurray, Christopher L. Middleton |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Gestational Age Serotonergic Article Nalidixic Acid chemistry.chemical_compound Sex Factors Cocaine Developmental Neuroscience Pregnancy Dopamine Fluoxetine Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Animals Lactation Attention Rats Long-Evans Tissue Distribution Naphthyridines Maternal-Fetal Exchange 5-HT receptor Neurons Dose-Response Relationship Drug Brain Oxytocin receptor Rats Ventral tegmental area medicine.anatomical_structure Endocrinology Animals Newborn chemistry Oxytocin Receptors Oxytocin Hypothalamus Amfonelic acid Prenatal Exposure Delayed Effects Injections Intravenous Female Psychology hormones hormone substitutes and hormone antagonists Protein Binding Developmental Biology medicine.drug |
| Zdroj: | International Journal of Developmental Neuroscience. 22:321-328 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2004.03.002 |
| Popis: | Cocaine administered chronically throughout gestation has been correlated with deficits in maternal behavior, increased maternal aggressive behavior and decreased oxytocin levels in rats. In addition to its effects on oxytocin levels, cocaine is a potent serotonergic, dopaminergic and noradrenergic reuptake inhibitor. Alterations in the dopaminergic and serotonergic systems have been suggested as possibly having a role in cocaine-induced maternal aggression. This study was in part, an attempt to understand some of the mechanisms by which cocaine increases postpartum aggression, particularly as they relate to changes in the oxytocin system. Oxytocin receptor number and binding affinity in the medial preoptic area of the hypothalamus, ventral tegmental area, hippocampus and amygdala were determined for lactating rat dams on postpartum day 6 (PPD 6) that were gestationally treated with cocaine, fluoxetine, saline or an amfonelic acid/fluoxetine drug combination. Cocaine and fluoxetine treatment both resulted in a significant up-regulation of oxytocin receptor number and lower receptor affinity in the amygdala of lactating rat dams compared to saline controls and the amfonelic acid/fluoxetine combination treatment group. Cocaine treatment also resulted in a significant down-regulation of oxytocin receptors in the medial preoptic area and both cocaine and fluoxetine treated dams had the highest affinity for oxytocin receptors in this brain region. Results of the present study support previous data indicating that alterations in oxytocinergic and perhaps serotonergic system dynamics in the amygdala may play a role in cocaine-induced postpartum aggression. |
| Databáze: | OpenAIRE |
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