Effect of Sedation with Midazolam or Propofol on Patient's Comfort During Cancer Chemotherapy Infusion: A Prospective, Randomized, Double-Blind Study in Breast Cancer Patients
| Autor: | G. Argun, F.N. Ertunc, S. Dikmen Mentes, O. Baran, Diclehan Ünsal |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Vomiting Nausea Midazolam Sedation Antineoplastic Agents Breast Neoplasms Anxiety law.invention Breast cancer Double-Blind Method Randomized controlled trial law Humans Medicine Pharmacology (medical) Propofol Pharmacology business.industry Middle Aged medicine.disease Regimen Infectious Diseases Oncology Patient Satisfaction Anesthesia Female medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | Journal of Chemotherapy. 17:327-333 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.2005.17.3.327 |
| Popis: | Nausea, vomiting and anxiety related to administration of cancer chemotherapy remain significant problems. This randomized, clinical trial was undertaken to evaluate the effect of sedation on the patient's comfort during chemotherapy infusion in patients with breast cancer. Forty-five breast cancer patients were randomized into three groups: Group I - chemotherapy, control, Group II - midazolam+chemotherapy, and Group III - propofol+chemotherapy. Nausea occured in 87% and vomiting in 13% of the patients in the control group, while none of the sedated subjects had these side-effects, although 76% of them had experienced then during previous cycles of chemotherapy. Compared with the control group, post-chemotherapy anxiety scores also improved with the addition of midazolam or propofol. Eighty percent of the subjects declared that they would prefer the sedative-containing regimen for their further cycles. Sedation with midazolam or propofol may improve the patient's comfort, and provide better control of chemotherapy-related side effects during chemotherapy infusion in breast cancer patients. |
| Databáze: | OpenAIRE |
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