Evaluation of cerebrovascular reactivity in chronic hepatitis C patients using transcranial color Doppler

Autor: Ivo Ivić, Mirela Pavicic Ivelja, Antonio Mestrovic, Stipan Janković, Kresimir Dolic, Nikola Perkovic
Jazyk: angličtina
Rok vydání: 2019
Předmět:
RNA viruses
Male
Chronic Hepatitis
Gastroenterology and hepatology
Ultrasonography
Doppler
Transcranial
Hemodynamics
Hepacivirus
medicine.disease_cause
Systemic inflammation
Vascular Medicine
Hepatitis
Chronic Liver Disease
Stroke
Immune Response
Pathology and laboratory medicine
Multidisciplinary
Alcohol Consumption
Hepatitis C virus
Hepatitis C
Medical microbiology
Middle Aged
Infectious hepatitis
Neurology
Cerebrovascular Circulation
Viruses
Cardiology
Medicine
Infectious diseases
Female
medicine.symptom
Pathogens
Blood Flow Velocity
Research Article
Adult
medicine.medical_specialty
Science
Cerebrovascular Diseases
Immunology
Viral diseases
Microbiology
Sepsis
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Humans
Liver diseases
Nutrition
Medicine and health sciences
Inflammation
Biology and life sciences
Flaviviruses
business.industry
Organisms
Viral pathogens
Hepatitis C
Chronic
medicine.disease
Atherosclerosis
Hepatitis viruses
Transcranial Doppler
Microbial pathogens
Diet
cerebrovascular disorders
haemodynamics
chronic
middle cerebral artery
Ultrasonography
business
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218206 (2019)
ISSN: 1932-6203
Popis: Hepatitis C viral (HCV) infection is associated with systemic inflammation and metabolic complications that might predispose patients to atherosclerosis, including cerebrovascular atherosclerosis. The aim of this study was to assess cerebrovascular reactivity in patients with chronic hepatitis C. Seventeen patients with chronic hepatitis C infection, as well as 11 healthy blood donors in the control group, were assessed for cerebrovascular reactivity according to the well-established breath- holding test that uses the transcranial color Doppler for measurement of blood flow velocity. Results obtained during the breath-holding revealed significantly lower average peak systolic (AvPS start, P = 0.018), end-diastolic (AvED start, P = 0.031) and mean velocity values at the very beginning of the breath-holding procedure (AvmeanV start, P = 0.02), as well as a lower mean peak systolic velocity at the end of the breath-holding test (AvPS max, P = 0.02) in the hepatitis C group. Vascular reactivity values, calculated as the breath-holding index, were also significantly lower (P = 0.045) in the hepatitis C group. In conclusion, the results of this study suggest an association between chronic HCV infection and altered cerebrovascular reactivity which may ultimately have an unfavorable effect on cerebrovascular hemodynamics and lead to increased risk of cerebrovascular diseases.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje