Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations
| Autor: | Anne Cecilie K Larstorp, Sverre E. Kjeldsen, Eirik Olsen, Ulla Hjørnholm, Ylva M Fauchald, Sondre Heimark, Knut Liestøl, Christian W Thorstensen, Vibeke N. Kjær, Marit Dahl Solbu, Camilla Lund Søraas, Aud Høieggen, Eva Gerdts, Stine Rognstad, Morten Rostrup, Fadl Elmula M. Fadl Elmula, Ola Undrum Bergland, Rune Mo, Mimi Stokke Opdal, Arleen Aune, Karl Marius Brobak, Lene V Halvorsen |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty media_common.quotation_subject Diastole Blood Pressure 030204 cardiovascular system & hematology Medication Adherence 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Internal medicine Internal Medicine medicine Humans In patient 030212 general & internal medicine Medical prescription Antihypertensive Agents media_common Aged business.industry Middle Aged Blood pressure Pill Ambulatory Hypertension Female Ultra high performance business Chromatography Liquid |
| Zdroj: | Hypertension |
| ISSN: | 0194-911X |
| Popis: | Nonadherence to drugs is a challenge in hypertension treatment. We aimed to assess the prevalence of nonadherence by serum drug concentrations compared with 2 indirect methods and relate to the prescribed drug regimens in a nationwide multicenter study. Five hundred fifty patients with hypertension using ≥2 antihypertensive agents participated. We measured concentrations of 23 antihypertensive drugs using ultra high performance liquid chromatography tandem mass-spectrometry and compared with patients’ self-reports and investigators’ assessment based on structured interview. We identified 40 nonadherent patients (7.3%) using serum drug concentrations. They had higher office diastolic blood pressure (90 versus 83 mm Hg, P P P P =0.03). Prescription of fixed-dose combination pills were lower among the nonadherent patients identified by serum concentrations (45.0 versus 67.1%, P Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03209154. |
| Databáze: | OpenAIRE |
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