Surgical Compared with Nonoperative Treatment for Lumbar Degenerative Spondylolisthesis
| Autor: | Wenyan Zhao, Tor D. Tosteson, Emily A. Blood, James Neil Weinstein, Serena S. Hu, Jon D. Lurie, Michael Longley, Anna N. A. Tosteson, Lawrence G. Lenke, Harry N. Herkowitz, Nancy J. O. Birkmeyer, Sanford E. Emery |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Scientific Articles medicine.medical_specialty Time Factors Spinal stenosis Severity of Illness Index law.invention Postoperative Complications Spinal Stenosis Patient satisfaction Randomized controlled trial Predictive Value of Tests law Confidence Intervals Humans Medicine Orthopedics and Sports Medicine Physical Therapy Modalities Aged Pain Measurement Probability Cross-Over Studies Lumbar Vertebrae business.industry General Medicine Middle Aged Decompression Surgical medicine.disease Combined Modality Therapy Spondylolisthesis Surgery Oswestry Disability Index Spinal Fusion Treatment Outcome Patient Satisfaction Orthopedic surgery Cohort Linear Models Physical therapy Female Observational study business Follow-Up Studies |
| Zdroj: | The Journal of Bone and Joint Surgery-American Volume. 91:1295-1304 |
| ISSN: | 0021-9355 |
| DOI: | 10.2106/jbjs.h.00913 |
| Popis: | Background: The management of degenerative spondylolisthesis associated with spinal stenosis remains controversial. Surgery is widely used and has recently been shown to be more effective than nonoperative treatment when the results were followed over two years. Questions remain regarding the long-term effects of surgical treatment compared with those of nonoperative treatment. Methods: Surgical candidates from thirteen centers with symptoms of at least twelve weeks' duration as well as confirmatory imaging showing degenerative spondylolisthesis with spinal stenosis were offered enrollment in a randomized cohort or observational cohort. Treatment consisted of standard decompressive laminectomy (with or without fusion) or usual nonoperative care. Primary outcome measures were the Short Form-36 (SF-36) bodily pain and physical function scores and the modified Oswestry Disability Index at six weeks, three months, six months, and yearly up to four years. Results: In the randomized cohort (304 patients enrolled), 66% of those randomized to receive surgery received it by four years whereas 54% of those randomized to receive nonoperative care received surgery by four years. In the observational cohort (303 patients enrolled), 97% of those who chose surgery received it whereas 33% of those who chose nonoperative care eventually received surgery. The intent-to-treat analysis of the randomized cohort, which was limited by nonadherence to the assigned treatment, showed no significant differences in treatment outcomes between the operative and nonoperative groups at three or four years. An as-treated analysis combining the randomized and observational cohorts that adjusted for potential confounders demonstrated that the clinically relevant advantages of surgery that had been previously reported through two years were maintained at four years, with treatment effects of 15.3 (95% confidence interval, 11 to 19.7) for bodily pain, 18.9 (95% confidence interval, 14.8 to 23) for physical function, and −14.3 (95% confidence interval, −17.5 to −11.1) for the Oswestry Disability Index. Early advantages (at two years) of surgical treatment in terms of the secondary measures of bothersomeness of back and leg symptoms, overall satisfaction with current symptoms, and self-rated progress were also maintained at four years. Conclusions: Compared with patients who are treated nonoperatively, patients in whom degenerative spondylolisthesis and associated spinal stenosis are treated surgically maintain substantially greater pain relief and improvement in function for four years. Level of Evidence: Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence. |
| Databáze: | OpenAIRE |
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