Functionalizing the glycocalyx of living cells with supramolecular guest ligands for cucurbit[8]uril-mediated assembly

Autor:	Wies van Roosmalen, Jurriaan Huskens, Mark L. Verheijden, Emanuela Cavatorta, Jens Voskuhl, Pascal Jonkheijm
Přispěvatelé:	Faculty of Science and Technology, Molecular Nanofabrication
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Bridged-Ring Compounds Azides Stereochemistry Macromolecular Substances Lipid Bilayers Supramolecular chemistry 02 engineering and technology Naphthols 010402 general chemistry Glycocalyx Ligands 01 natural sciences Catalysis Jurkat Cells Materials Chemistry Leukocytes Humans Lipid bilayer Cells Cultured Molecular Structure Chemistry Cell Membrane Metals and Alloys Imidazoles General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry Cycloaddition n/a OA procedure 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Metabolic labeling Alkynes Ceramics and Composites 0210 nano-technology
Zdroj:	Chemical communications, 52(44), 7146-7149. Royal Society of Chemistry
ISSN:	1359-7345
Popis:	Multiple naphthol ligands were installed on the glycocalyx of white blood cells via metabolic labeling and subsequent strain promoted azide–alkyne cycloaddition. Only when cucurbit[8]uril was present to drive the formation of ternary complexes, cells specifically assembled on a methylviologen functionalized supported lipid bilayer through multivalent interactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4f4e36be0a8627c581cf9fc2b2839e https://research.utwente.nl/en/publications/1a230a2c-6f26-4452-8726-68ed27a1049c Zobrazit plný text záznamu