The effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on testicular steroidogenesis in infantile male rats
| Autor: | Matti Viluksela, Jorma Paranko, N. A. Adamsson, Tapio Haavisto, S. A. Myllymäki, Leon J. S. Brokken, Jorma Toppari |
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| Rok vydání: | 2006 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Polychlorinated Dibenzodioxins Offspring medicine.drug_class Urology Endocrinology Diabetes and Metabolism Population Testicle Biology Rats Sprague-Dawley Fetus Pregnancy Internal medicine Testis medicine Cyclic AMP Animals Testosterone education reproductive and urinary physiology education.field_of_study Leydig cell Dose-Response Relationship Drug Leydig Cells Organ Size Luteinizing Hormone Androgen Rats medicine.anatomical_structure Endocrinology Reproductive Medicine Animals Newborn Maternal Exposure Environmental Pollutants Female Follicle Stimulating Hormone Luteinizing hormone Hormone |
| Zdroj: | International journal of andrology. 29(2) |
| ISSN: | 0105-6263 |
| Popis: | Exposure of adult male animals to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) decreases serum androgen concentrations. Reduction in androgen levels after maternal exposure has also been reported, but these results have not been reproduced. We have earlier shown that TCDD stimulates rather than inhibits testosterone synthesis in the prenatal rat testis. The aim of the present study was to elucidate in utero-induced effects of TCDD on testicular steroidogenesis in the 14-day-old infant rats. At that time the foetal Leydig cell population is still the prevailing source of androgens. Pregnant Sprague-Dawley dams were given a single oral dose of TCDD (0, 0.04, 0.2, or 1.0 microg/kg) on day 13 of pregnancy. On postnatal day 14, the body weight of male offspring was reduced after exposure to 1.0 microg/kg TCDD (from 33.9 +/- 1.66 g to 31.6 +/- 2.67 g). Relative testis weight, plasma testosterone, luteinizing hormone and follicle-stimulating hormone levels remained unaltered in all exposure groups. Moreover, in ex vivo incubations, testosterone and cAMP production was not affected. StAR protein level in the freshly isolated testes was increased in the 0.2 microg/kg group, and seminiferous cord diameter in the 0.04 microg/kg group. The present study confirms our earlier findings in in utero TCDD-exposed foetal testis indicating that maternal TCDD exposure does not negatively influence the developmental testosterone production of foetal type Leydig cells in rats. |
| Databáze: | OpenAIRE |
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