Association between angiotensin‐converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case‐controlled study
| Autor: | Samah Ezzat Ibrahim, Ola S El-Shimi, Eman Fawzy, Naglaa F. Alhusseini, Amany Ibrahim Mustafa, Yasser Mostafa Gohary |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Angiotensins education Dermatology Peptidyl-Dipeptidase A Gastroenterology Polymorphism (computer science) Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele Family history Gene reproductive and urinary physiology Polymorphism Genetic biology business.industry Case-control study Alopecia Angiotensin-converting enzyme female genital diseases and pregnancy complications body regions Mutagenesis Insertional Case-Control Studies biology.protein Egypt Gene polymorphism business |
| Zdroj: | Journal of Cosmetic Dermatology. 21:2629-2634 |
| ISSN: | 1473-2165 1473-2130 |
| DOI: | 10.1111/jocd.14434 |
| Popis: | BACKGROUND Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin-converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility. OBJECTIVES In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients. METHODS This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction. RESULTS The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p |
| Databáze: | OpenAIRE |
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