Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype
| Autor: | Virgínia Berlanga Campos Junqueira, Valéria P. Lanzoni, Mariliza M B Leite-Mor, Ana Cláudia de Oliveira, Regina Maria Catarino, Edison Roberto Parise, Karin A. Simon |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Hepacivirus Biology medicine.disease_cause Biochemistry Superoxide dismutase Young Adult Insulin resistance Internal medicine medicine TBARS Humans Aged chemistry.chemical_classification Hepatitis Glutathione peroxidase Fatty liver General Medicine Hepatitis C Chronic Middle Aged medicine.disease Fatty Liver Oxidative Stress Endocrinology chemistry biology.protein Female Insulin Resistance Steatosis Biomarkers Oxidative stress |
| Zdroj: | Free Radical Research. 43:1187-1194 |
| ISSN: | 1029-2470 1071-5762 |
| DOI: | 10.3109/10715760903247249 |
| Popis: | Modifications of oxidative stress are reported in hepatitis C. The relationship between insulin resistance (IR), steatosis and oxidative stress is not established.One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. In the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined.In non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. In the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p=0.019), beta-carotene (p=0.006), lycopene (p=0.005) and GPx (p=0.009).In non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |