Outcomes of cryoballoon or radiofrequency ablation in symptomatic paroxysmal or persistent atrial fibrillation
| Autor: | Dietrich Andresen, Jochen Senges, Andreas Metzner, Karl-Heinz Kuck, Julian Kyoung Ryul Chun, Ellen Hoffmann, Taoufik Ouarrak, Roland Richard Tilz, Johannes Brachmann, Georg Noelker, Li-Qun Wu, Jürgen Tebbenjohanns, Malte Kuniss, Arcadi García-Alberola, Uwe Dorwarth, Florian Straube, Andreas Franke, Christoph Stellbrink, Karl Wegscheider |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Reoperation medicine.medical_specialty Radiofrequency ablation medicine.medical_treatment Population Paroxysmal Operative Time Catheter ablation Lower risk Cryoballoon Radiation Dosage Cryosurgery Patient Readmission law.invention Cohort Studies Postoperative Complications law Clinical Research Recurrence Physiology (medical) Internal medicine Atrial Fibrillation medicine Clinical endpoint Persistent Humans Prospective Studies Adverse effect education Aged Proportional Hazards Models education.field_of_study business.industry Hazard ratio Atrial fibrillation Middle Aged medicine.disease Ablation for Atrial Fibrillation Editor's Choice surgical procedures operative Treatment Outcome Radiofrequency Cardiology Catheter Ablation Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Europace |
| ISSN: | 1532-2092 1099-5129 |
| Popis: | Aims To evaluate the effectiveness and safety of cryoballoon ablation (CBA) compared with radiofrequency ablation (RFA) for symptomatic paroxysmal or drug-refractory persistent atrial fibrillation (AF). Methods and results Prospective cluster cohort study in experienced CBA and RFA centres. Primary endpoint was ‘atrial arrhythmia recurrence’, secondary endpoints were as follows: procedural results, safety, and clinical course. A total of 4189 patients were included: CBA 2329 (55.6%) and RFA 1860 (44.4%). Cryoballoon ablation population was younger, with fewer comorbidities. Procedure time was longer in the RFA group (P = 0.01). Radiation exposure was 2487 (CBA) and 1792 cGycm2 (RFA) (P Conclusions The primary endpoint did not differ between CBA and RFA. Cryoballoon ablation was completed rapidly; the radiation exposure was greater. Rehospitalization due to re-ablations and adverse events during follow-up were observed significantly less frequently after CBA than after RFA. Subgroup analysis suggested a lower risk of recurrence after CBA in paroxysmal AF. Trial Registration ClinicalTrials.gov (NCT01360008), https://clinicaltrials.gov/ct2/show/NCT01360008. |
| Databáze: | OpenAIRE |
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