Ratio between inner cell mass diameter and blastocyst diameter is correlated with successful pregnancy outcomes of single blastocyst transfers
| Autor: | Zeev Shoham, Sheila Fieldust, Yael Harir, Miriam Almagor, Yuval Or |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Clinical pregnancy Biology Time-Lapse Imaging Intracytoplasmic sperm injection Andrology Embryo Culture Techniques 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Pregnancy medicine Single Embryo Transfer Inner cell mass Humans Blastocyst Embryo Implantation Sperm Injections Intracytoplasmic reproductive and urinary physiology Retrospective Studies Gynecology Academic Medical Centers 030219 obstetrics & reproductive medicine urogenital system Obstetrics and Gynecology Successful pregnancy medicine.disease Predictive value 030104 developmental biology medicine.anatomical_structure Fertility Treatment Outcome Reproductive Medicine Blastocyst Inner Cell Mass Infertility embryonic structures Female Live birth Live Birth |
| Zdroj: | Fertility and sterility. 106(6) |
| ISSN: | 1556-5653 |
| Popis: | Objective To evaluate the ability to predict pregnancy outcomes of single-blastocyst transfers by measuring the ratio of inner cell mass (ICM) diameter to blastocyst diameter using time-lapse images. Design Retrospective cohort study. Setting University-affiliated medical center. Patient(s) One hundred twenty-seven women undergoing a total of 129 blastocyst transfers with intracytoplasmic sperm injection. Intervention(s) Embryo monitoring by time-lapse microscopy. Main Outcome Measure(s) The ratio of ICM diameter to blastocyst diameter in single-blastocyst transfers and clinical pregnancy rates. Result(s) In phase I of the study, 63 women underwent 65 single blastocyst transfers that resulted in 25 pregnancies (40% of the women). The successfully implanted blastocysts had an average ICM/blastocyst diameter ratio of 0.487 ± 0.086, whereas the average ICM/blastocyst ratio of nonimplanted blastocysts was significantly lower (0.337 ± 0.086). The live-birth rate was 29% (18/63). In phase II, 64 single-blastocyst transfers were performed in 64 women. The ICM/blastocyst diameter ratio was measured, and blastocysts with the highest ratios were chosen for transfer. Forty-three women (67%) with an average ICM/blastocyst diameter ratio of 0.46 achieved pregnancy, and 36 of the 43 pregnancies (84%) resulted in the delivery of a healthy baby. In the 21 women (33%) who failed to achieve pregnancy, the average ICM/blastocyst ratio was 0.45. The resultant positive predictive value was 74%, and the negative predictive value was 70%. Conclusion(s) The ICM-to-blastocyst diameter ratio is a predictor of implantation and live birth in single-blastocyst transfers, offering a simple, noninterfering method to select blastocysts with high developmental capacity. |
| Databáze: | OpenAIRE |
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