Chronic Vitamin E Administration Improves Brachial Reactivity and Increases Intracellular Magnesium Concentration in Type II Diabetic Patients
| Autor: | Michele Varricchio, Giuseppe Paolisso, Guido Antonio Zito, Emilia Ragno, G. Varricchio, Michelangela Barbieri, Antonio Gambardella, Maria Tagliamonte |
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| Přispěvatelé: | Paolisso, Giuseppe, Tagliamonte, Mr, Barbieri, Michelangela, Zito, Ga, Gambardella, Antonio, Varricchio, G, Ragno, E, Varricchio, M. |
| Rok vydání: | 2000 |
| Předmět: |
Blood Glucose
Male Lipid Peroxides medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Hemodynamics Calcium medicine.disease_cause Thiobarbituric Acid Reactive Substances Biochemistry Lipid peroxidation chemistry.chemical_compound Endocrinology Double-Blind Method Internal medicine Diabetes mellitus medicine.artery medicine Humans Vitamin E Brachial Plexus Magnesium Brachial artery Cholesterol business.industry Biochemistry (medical) Middle Aged medicine.disease Glutathione Oxidative Stress Diabetes Mellitus Type 2 chemistry Body Composition Female business Oxidative stress |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 85:109-115 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.85.1.6258 |
| Popis: | Vascular disease accounts for the majority of the clinical complications in diabetes mellitus. As an exaggerated oxidative stress degree has been postulated as the link between diabetes mellitus and endothelial function, a possible positive effect of plasma vitamin E (Vit.E) administration on brachial reactivity could be postulated. Our study aims at investigating the possible effect of chronic Vit.E administration on brachial reactivity, oxidative stress indexes, and intracellular magnesium and calcium content in type II diabetic patients free of diabetic complications. Forty adult, type II diabetic patients were enrolled in the study, which was deigned as a double blind, randomized vs. placebo trial. At baseline all patients underwent the following tests: 1) anthropometric and metabolic examinations, 2) evaluation of oxidative stress indexes, 3) intracellular magnesium and calcium measurements, and 4) determination of arterial compliance and distensibility. Then, all patients were randomly assigned to Vit.E treatment at a dose of 600 mg/day (Evion Forte; n = 20) or placebo (n = 20) over 8 weeks. At the end of this treatment period, a complete reevaluation of the patients was made. Vit.E treatment was associated with a significant improvement in the percent change in brachial artery diameter (P |
| Databáze: | OpenAIRE |
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