Protective effect of human urinary thrombomodulin on ischemia- reperfusion injury in the canine liver
| Autor: | Kunihiro Yamazaki, Naoki Joubara, A. Mitumaru, Tadaaki Shiba, H. Satake, Y. Miki, Hironori Kaneko, Masaaki Yoshino |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Pathology Endothelium Urinary system Thrombomodulin Ischemia Blood Pressure Urine Gastroenterology Dogs Internal medicine medicine Coagulopathy Animals Humans cardiovascular diseases Hyaluronic Acid biology Vascular disease business.industry Fissipedia medicine.disease biology.organism_classification Blood Cell Count Microscopy Electron medicine.anatomical_structure Liver Reperfusion Injury Surgery Blood Coagulation Tests business Reperfusion injury Liver Circulation |
| Zdroj: | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 32(2) |
| ISSN: | 0014-312X |
| Popis: | This study was performed to determine whether human urinary soluble thrombomodulin plays a role in liver ischemia-reperfusion injury. Liver ischemia was induced in two groups of dogs. Group 1 was exposed to 60 min ischemia, and group 2 was exposed to 60 min ischemia after preischemic administration of human urinary soluble thrombomodulin. In group 1, the thrombin-antithrombin complex and hyaluronic acid were significantly elevated after ischemia, compared with the preischemic values. While liver issue blood flow and the plasmin-α2-plasmin inhibitor complex significantly decreased, AST, ALT and m-AST dramatically increased after reperfusion. In group 2, the increase in the thrombin-antithrombin complex and hyaluronic acid was significantly suppressed, and AST, ALT and liver tissue blood flow significantly improved, compared with group 1. Histologically, in group 2, the hepatic tissue structure, including endothelial cells, was relatively intact. These findings suggest that administration of thrombomodulin inhibits endothelial cell injury and coagulopathy and offers protection from liver ischemia-reperfusion injury. |
| Databáze: | OpenAIRE |
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