Identifying risk of viral failure in treated hiv-infected patients using different measures of adherence: the antiretroviral therapy cohort collaboration
| Autor: | Jonathan A C Sterne, Margaret T May, Heidi M Crane, Nikola Hanhoff, Jodie L. Guest, Tracy R. Glass, Viviane D. Lima, Michael J. Mugavero, Adriana Ammassari, Jan Tate, M. John Gill, Suzanne M Ingle, Benita Yip, Nicholas L Turner |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty antiretroviral therapy Human immunodeficiency virus (HIV) lcsh:Medicine Pharmacy medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine cohort studies Internal medicine medicine HIV adherence viral failure Hiv infected patients 030212 general & internal medicine business.industry lcsh:R General Medicine Odds ratio 030112 virology Antiretroviral therapy 3. Good health Cohort business Viral load Cohort study |
| Zdroj: | Ingle, S, Crane, H M, Glass, T R, Yip, B, Lima, V D, Gill, M J, Hanhoff, N, Ammassari, A, Mugavero, M J, Tate, J P, Guest, J L, Turner, N, May, M & Sterne, J 2018, ' Identifying risk of viral failure in treated HIV-infected patients using different measures of adherence : the Antiretroviral Therapy Cohort Collaboration ', Journal of Clinical Medicine, vol. 7, no. 10, 328 . https://doi.org/10.3390/jcm7100328 Journal of Clinical Medicine, Vol 7, Iss 10, p 328 (2018) Journal of Clinical Medicine Journal of Clinical Medicine; Volume 7; Issue 10; Pages: 328 |
| DOI: | 10.3390/jcm7100328 |
| Popis: | Adherence to antiretroviral therapy (ART) is critical for successful treatment of Human Immunodeficiency Virus (HIV), but comparisons across settings are difficult because adherence is measured in different ways. We examined utility of different adherence measures for identification of patients at risk of viral failure (VF). Eight cohorts in the ART Cohort Collaboration contributed data from pharmacy refills or self-report questionnaires collected between 1996 and 2013 (N = 11689). For pharmacy data (N = 7156), we examined associations of percentage adherence during the 1st year of ART with VF (>500 copies/mL) at 1 year. For self-report data (N = 4533), we examined 28-day adherence with VF based on closest viral load measure within 6 months after questionnaire date. Since adherence differed markedly by measurement type, we defined different cut-off points for pharmacy (lower |
| Databáze: | OpenAIRE |
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