Autoimmune thrombocytopenic purpura in partial DiGeorge syndrome: case presentation
| Autor: | Sara Elva Espinosa-Padilla, Esther Lieberman-Hernández, Marco Antonio Yamazaki-Nakashimada, Leticia Hernández-Nieto |
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| Rok vydání: | 2011 |
| Předmět: |
Purpura
Thrombocytopenic Idiopathic Adolescent business.industry Incidence (epidemiology) Lymphocyte Hematology Case presentation medicine.disease_cause medicine.disease Autoimmune thrombocytopenia Autoimmunity medicine.anatomical_structure Oncology DiGeorge syndrome Pediatrics Perinatology and Child Health Immunology Primary immunodeficiency DiGeorge Syndrome Medicine Humans Female Central tolerance Chromosome Deletion business |
| Zdroj: | Journal of pediatric hematology/oncology. 33(6) |
| ISSN: | 1536-3678 |
| Popis: | The absence of an appropriate central tolerance in primary immunodeficiencies favors proliferation of autoreactive lymphocyte clones, causing a greater incidence of autoimmunity. Del 22q11.2 syndrome presents an increased incidence of allergic and autoimmune diseases. One of the most relevant and frequent immune manifestations is autoimmune thrombocytopenia. We present the case of a pediatric patient with autoimmune thrombocytopenia due to the immunological dysregulation observed in partial DiGeorge syndrome. |
| Databáze: | OpenAIRE |
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