Clinical reactions to systemic provocation with gold sodium thiomalate in patients with contact allergy to gold
| Autor: | Magnus Bruze, Bert Björkner, Halvor Möller |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Allergy medicine.medical_specialty Fever Provocation test Dermatology Placebo medicine.disease_cause Gold Sodium Thiomalate Allergen Double-Blind Method medicine Humans Aged business.industry Middle Aged Patch Tests Gold Sodium Thiosulfate medicine.disease Dermatitis Allergic Contact Toxicity Immunology Gold salts Female business Haptens Immunologic Memory Contact dermatitis medicine.drug |
| Zdroj: | British Journal of Dermatology. 135:423-427 |
| ISSN: | 0007-0963 |
| DOI: | 10.1046/j.1365-2133.1996.d01-1015.x |
| Popis: | In a double blind experimental study, 20 patients with a contact allergy to gold sodium thiosulphate were challenged intramuscularly with the chemically similar gold sodium thiomalate and with placebo. The most spectacular clinical reaction in the 10 patients given the active agent, was an epidermal and dermal flare up of healed patch-test reactions to the gold salts, as well as a high, but transient, rise in body temperature. Previous intradermal tests were similarly reactivated. In addition, toxicoderma-like rashes were observed in several cases, but a flare up of a previous contact dermatitis site was seen in one patient only. The specificity of the positive provocations was demonstrated. |
| Databáze: | OpenAIRE |
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