Seroprevalence of Helicobacter pylori infection in patients with lymphoma

Autor:	James A. Strauchen, Janet Cuttner, Shunichiro Ogata, Kevin Troy, Pat McGlynn, J. Lawrence Werther, Anli Chen, Carol A. Bodian, Steven H. Itzkowitz
Rok vydání:	2001
Předmět:	Adult Male Cancer Research Helicobacter pylori infection medicine.medical_specialty Adolescent Lymphoma Lymphoproliferative disorders Disease Gastroenterology Helicobacter Infections Myeloproliferative Disorders immune system diseases Seroepidemiologic Studies hemic and lymphatic diseases Internal medicine medicine Seroprevalence Humans In patient Child Aged Aged 80 and over biology Helicobacter pylori business.industry Hematology Middle Aged medicine.disease biology.organism_classification Oncology Immunology Female business
Zdroj:	Leukemialymphoma. 40(5-6)
ISSN:	1042-8194
Popis:	To determine the Helicobacter pylori (HP) seroprevalence in patients with non-Hodgkin's lymphoma (NHL) and other hematological conditions. Sera were collected from 444 patients with NHL, Hodgkin's disease (HD), lymphoproliferative disorders (LPD), myeloproliferative disorders (MPD), and other hematological conditions. HP seropositivity was determined by ELISA and the results were compared among diagnostic groups HP seropositivity was observed in 168/444 (38%) of the total population. Higher seropositivity rates were associated with increasing age (p=0.001), and country of birth outside the USA and Canada (p=0.0001). Among the diagnostic groups, patients with NHL demonstrated the highest frequency (43%) and those with HD, the lowest frequency (20%; p=.026) of HP seropositivity. The differences among diagnostic groups remained statistically significant after controlling for country of birth (p0.05), but not after controlling for patient age at diagnosis. The HP seroprevalence of G1 NHL was 55% compared to 40% for non-G1 NHL (p=NS). The highest rate of HP seropositivity (67%) occurred in gastric MALT lymphoma patients, although this did not reach statistical significance compared to the non MALT group (50%) due to small sample size. In conclusion, the rate of HP seropositivity in patients with MALT lymphoma in the USA appears to be lower than in Europe. Helicobacter pylori does not appear to be an important factor in other types of NHL of the G1 tract or elsewhere. Studies of HP prevalence should be controlled for country of birth as well as for age.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799d55c52c2964737e93c1fc1e10ed70 https://pubmed.ncbi.nlm.nih.gov/11426531 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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