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Ke Zeng,1,* Jia-Mo Zhang,2,* Xiao-Bin Li,1 Sheng-Xian Peng,3 Su-Chuan Zhang,4 Wen-Xian Xie,5 Chun-Fang Xi,1 Cheng-Jian Cao6 1Department of Urology, First Peopleâs Hospital of Zigong City, Zigong, Peopleâs Republic of China; 2Department of Urology, YongChuan Hospital Chongqing Medical University, Chongqing, Peopleâs Republic of China; 3Scientific Research Department, First Peopleâs Hospital of Zigong City, Zigong, Peopleâs Republic of China; 4Laboratory Department, First Peopleâs Hospital of Zigong City, Zigong, Peopleâs Republic of China; 5Department of Basic Medicine, Sichuan Vocational College of Health and Rehabilitation, Zigong, Peopleâs Republic of China; 6Zigong Academy of Medical Sciences, First Peopleâs Hospital of Zigong City, Zigong, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Cheng-Jian CaoZigong Academy of Medical Sciences, First Peopleâs Hospital of Zigong City, Zigong, Peopleâs Republic of ChinaEmail cccjj2011@163.comObjective: To analyze the bacterial biofilm (BF) formation in patients with malignancy undergoing double J stent indwelling and its influencing factors.Methods: A total of 167 patients with malignant tumors who received double J stent indwelling in the hospital from January 2018 to January 2021 were included in the study. The urine and double J stent samples were collected for bacterial identification and observed for BF formation on the surface of the urinary catheter under a scanning electron microscope (SEM). Univariate and multivariate logistic regression analyses were used to analyze the influencing factors of BF.Results: The BF formation rate was 34.73% (58/167). The BF formation rate of positive specimens cultured in urine and double J stent was significantly higher than that of negative ones (P< 0.05). Staphylococcus was the main BF bacteria in double J stent and urine culture specimens, followed by Enterococcus, Pseudomonas, Enterobacter, and Acinetobacter. Compared with the non-BF group, the number of viable bacteria in the double J stent and urine and the catheterization time in the BF group rose markedly (P< 0.05). Advanced age, chemotherapy, anemia, indwelling time ⥠90d, and urinary tract infection were risk factors for BF formation in patients with malignancy undergoing double J stent indwelling (P< 0.05).Conclusion: There is a high rate of BF formation in patients with malignancy undergoing double J stent indwelling, with Staphylococcus as the dominant species. Treatment requires enhanced urinary catheter management and nutritional status to inhibit BF formation and lower the rate of urinary catheter-related infections.Keywords: malignant tumor, double J stent indwelling, biofilm, catheter-related infection, etiology, influence factor |
