Soft tissue sarcomas of the trunk wall (STS-TW): a study of 343 patients from the French Sarcoma Group (FSG) database
| Autor: | F. Collin, P. Terrier, I. Valo, J. J. Michels, Louis Guillou, B. Marques, Sébastien Salas, M. Trassard, J.-M. Coindre, V. Brouste, Binh Bui, E. Stoeckle, Agnès Leroux, Dominique Ranchère-Vince, Yves-Marie Robin |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Multivariate analysis Adolescent medicine.medical_treatment education Aged Aged 80 and over Databases as Topic Female Humans Middle Aged Sarcoma/mortality Sarcoma/pathology Survival Analysis Young Adult computer.software_genre Abdominal wall medicine Database business.industry Soft tissue sarcoma Soft tissue Cancer Sarcoma Hematology medicine.disease Radiation therapy medicine.anatomical_structure Oncology business computer Thoracic wall |
| Zdroj: | Annals of Oncology, vol. 20, no. 6, pp. 1127-1135 |
| Popis: | BACKGROUND: Soft tissue sarcomas of the trunk wall (STS-TW) are usually studied together with soft tissue sarcomas of other locations. We report a study on STS-TW forming part of the French Sarcoma Group database. PATIENTS AND METHODS: Three hundred and forty-three adults were included. We carried out univariate and multivariate analysis for overall survival (OS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS). RESULTS: Tumor locations were as follows: thoracic wall, 82.5%; abdominal wall, 12.3% and pelvic wall, 5.2%. Median tumor size was 6.0 cm. The most frequent tumor types were unclassified sarcoma (27.7%) and myogenic sarcoma (19.2%). A total of 44.6% of cases were grade 3. In all, 21.9% of patients had a previous medical history of radiotherapy (PHR). Median follow-up was 7.6 years. The 5-year OS, MFS and LRFS rates were 60.4%, 68.9% and 58.4%, respectively. Multivariate analysis retained PHR and grade for predicting LRFS and PHR, size and grade as prognostic factors of MFS. Factors influencing OS were age, size, PHR, depth, grade and surgical margins. The predictive factors of incomplete response were PHR, size and T3. CONCLUSIONS: Our results suggest similar classical prognostic factors as compared with sarcomas of other locations. However, a separate analysis of STS-TW revealed a significant poor prognosis subgroup of patients with PHR. |
| Databáze: | OpenAIRE |
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