Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabinoids: Emergency Department Presentations
| Autor: | Michael Wahl, Erik Wright, Douglas L. Feinstein, John W. Hafner, Steven E. Aks, Gregory Podolej, Richard B. van Breemen, Israel Rubinstein |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Vitamin K Difenacoum medicine.drug_class 030204 cardiovascular system & hematology Toxicology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Synthetic cannabinoids medicine Coagulopathy Humans Rodenticide 030212 general & internal medicine Retrospective Studies Original Research Cannabinoids RC86-88.9 business.industry Anticoagulant Rodenticides Medical emergencies. Critical care. Intensive care. First aid Retrospective cohort study General Medicine Emergency department medicine.disease United States humanities chemistry Emergency medicine Emergency Medicine Medicine Emergency Service Hospital business Brodifacoum medicine.drug |
| Zdroj: | Western Journal of Emergency Medicine, Vol 22, Iss 4 (2021) Western Journal of Emergency Medicine |
| ISSN: | 1936-900X |
| Popis: | Author(s): Wright, Erik; Hafner, John W.; Podolej, Gregory; Feinstein, Douglas L.; van Breemen, Richard; Rubinstein, Israel; Aks, Steven; Wahl, Michael | Abstract: Introduction: Synthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of 2018, over 160 documented cases of bleeding and prolonged coagulopathy occurred secondary to contaminated synthetic cannabinoids. Methods: We conducted a retrospective cohort study consisting of 38 patients to describe the initial emergency department (ED) presentation, diagnosis, and treatment. Results: Through serum testing we found that three long-acting anticoagulant rodenticides (LAAR) were detected in patients who had inhaled these tainted products: brodifacoum, difenacoum, and bromodialone.n Discussion: This study encompasses the largest ED presentation of LAAR poisoning via the inhalational route known to date.nConclusion: The emergency physician should be aware of the potential for tainted coingestants as the cause of undifferentiated coagulopathy. |
| Databáze: | OpenAIRE |
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