Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines, inflammation and oxidative stress
| Autor: | Chien-Ning Huang, Huei-Ting Lin, Chau-Jong Wang, Chiung-Huei Peng, Dai-Jung Chung |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Adipokine lcsh:TX341-641 medicine.disease_cause Diet High-Fat Superoxide dismutase 03 medical and health sciences Adipokines Non-alcoholic Fatty Liver Disease Internal medicine Hyperlipidemia medicine Animals Humans Obesity Rats Wistar Pharmacology 030109 nutrition & dietetics biology Adiponectin business.industry Interleukin-6 Plant Extracts Tumor Necrosis Factor-alpha Leptin Lipogenesis Fatty liver fungi lcsh:RM1-950 nutritional and metabolic diseases respiratory system medicine.disease Plant Leaves Oxidative Stress Endocrinology lcsh:Therapeutics. Pharmacology Liver biology.protein Morus business lcsh:Nutrition. Foods and food supply Oxidative stress Food Science |
| Zdroj: | Journal of Food and Drug Analysis, Vol 26, Iss 2, Pp 778-787 (2018) |
| ISSN: | 1021-9498 |
| Popis: | Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are regulated by the leptin and adiponectin. MLE could prevent obesity-related NAFLD via downregulating the lipogenesis enzymes while upregulating the lipolysis markers. Treatment of MLE, especially at 2%, enhanced the expression of superoxide dismutase (SOD) and clenched the oxidative stress of liver. MLE decreased the plasma level of leptin but increased adiponectin. The advantage of MLE is supposed mainly attributed to chlorogenic acid derivative. We suggest MLE, with promising outcome of research, could be nutraceutical to prevent obesity and related NAFLD. Keywords: Mulberry leaf, Non-alcoholic fatty liver, Adiponectin, Oxidative stress, Inflammation |
| Databáze: | OpenAIRE |
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