Fibulin-3 as a Blood and Effusion Biomarker for Pleural Mesothelioma
| Autor: | Michael Harbut, Jonathan Melamed, Lee Goodglick, Harvey I. Pass, Luis Chiriboga, Jessica S. Donington, Chandra Goparaju, Stephen Levin, Ming-Sound Tsao, Marc de Perrot, David Chia, Gary E. Goodman, Geoffrey Liu, Margaret E. Huflejt, Michele Carbone, Mark D. Thornquist |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Pleural effusion business.industry Area under the curve Cancer General Medicine respiratory system medicine.disease_cause medicine.disease Gastroenterology Article Asbestos respiratory tract diseases Effusion Internal medicine medicine Biomarker (medicine) Mesothelioma Pleural Neoplasm business |
| Zdroj: | New England Journal of Medicine. 367:1417-1427 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa1115050 |
| Popis: | A B S T R AC T BACKGROUND New biomarkers are needed to detect pleural mesothelioma at an earlier stage and to individualize treatment strategies. We investigated whether fibulin-3 in plasma and pleural effusions could meet sensitivity and specificity criteria for a robust biomarker. METHODS We measured fibulin-3 levels in plasma (from 92 patients with mesothelioma, 136 asbestos-exposed persons without cancer, 93 patients with effusions not due to mesothelioma, and 43 healthy controls), effusions (from 74 patients with mesothelioma, 39 with benign effusions, and 54 with malignant effusions not due to mesothelioma), or both. A blinded validation was subsequently performed. Tumor tissue was examined for fibulin-3 by immunohistochemical analysis, and levels of fibulin-3 in plasma and effusions were measured with an enzyme-linked immunosorbent assay. RESULTS Plasma fibulin-3 levels did not vary according to age, sex, duration of asbestos exposure, or degree of radiographic changes and were significantly higher in patients with pleural mesothelioma (105±7 ng per milliliter in the Detroit cohort and 113±8 ng per milliliter in the New York cohort) than in asbestos-exposed persons without mesothelioma (14±1 ng per milliliter and 24±1 ng per milliliter, respectively; P |
| Databáze: | OpenAIRE |
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